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dc.contributor.authorMcCallum, Gabrielle B-
dc.contributor.authorMorris, Peter S-
dc.contributor.authorGrimwood, Keith-
dc.contributor.authorMaclennan, Carolyn-
dc.contributor.authorWhite, Andrew V-
dc.contributor.authorChatfield, Mark D-
dc.contributor.authorSloots, Theo P-
dc.contributor.authorMackay, Ian M-
dc.contributor.authorSmith-Vaughan, Heidi-
dc.contributor.authorMcKay, Clare C-
dc.contributor.authorVersteegh, Lesley A-
dc.contributor.authorJacobsen, Nerida-
dc.contributor.authorMobberley, Charmaine-
dc.contributor.authorByrnes, Catherine A-
dc.contributor.authorChang, Anne B-
dc.date2015-
dc.date.accessioned2018-05-15T23:01:00Z-
dc.date.accessioned2018-10-04T22:11:23Z-
dc.date.available2018-05-15T23:01:00Z-
dc.date.available2018-10-04T22:11:23Z-
dc.date.issued2015-
dc.identifier.citationFrontiers in pediatrics 2015; 3: 32-
dc.identifier.issn2296-2360-
dc.identifier.urihttp://hdl.handle.net/10070/302227-
dc.description.abstractBronchiolitis is a major health burden in infants globally, particularly among Indigenous populations. It is unknown if 3 weeks of azithromycin improve clinical outcomes beyond the hospitalization period. In an international, double-blind randomized controlled trial, we determined if 3 weeks of azithromycin improved clinical outcomes in Indigenous infants hospitalized with bronchiolitis. Infants aged ≤24 months were enrolled from three centers and randomized to receive three once-weekly doses of either azithromycin (30 mg/kg) or placebo. Nasopharyngeal swabs were collected at baseline and 48 h later. Primary endpoints were hospital length of stay (LOS) and duration of oxygen supplementation monitored every 12 h until judged ready for discharge. Secondary outcomes were: day-21 symptom/signs, respiratory rehospitalizations within 6 months post-discharge and impact upon nasopharyngeal bacteria and virus shedding at 48 h. Two hundred nineteen infants were randomized (n = 106 azithromycin, n = 113 placebo). No significant between-group differences were found for LOS (median 54 h for each group, difference = 0 h, 95% CI: -6, 8; p = 0.8), time receiving oxygen (azithromycin = 40 h, placebo = 35 h, group difference = 5 h, 95% CI: -8, 11; p = 0.7), day-21 symptom/signs, or rehospitalization within 6 months (azithromycin n = 31, placebo n = 25 infants, p = 0.2). Azithromycin reduced nasopharyngeal bacterial carriage (between-group difference 0.4 bacteria/child, 95% CI: 0.2, 0.6; p < 0.001), but had no significant effect upon virus detection rates. Despite reducing nasopharyngeal bacterial carriage, three large once-weekly doses of azithromycin did not confer any benefit over placebo during the bronchiolitis illness or 6 months post hospitalization. Azithromycin should not be used routinely to treat infants hospitalized with bronchiolitis. The trial was registered with the Australian and New Zealand Clinical Trials Register: Clinical trials number: ACTRN1261000036099.-
dc.language.isoeng-
dc.subjectIndigenous-
dc.subjectazithromycin-
dc.subjectbacteria-
dc.subjectbronchiolitis-
dc.subjectmacrolides-
dc.subjectrandomized controlled trial-
dc.subjectrespiratory syncytial virus-
dc.subjectviruses-
dc.titleThree-weekly doses of azithromycin for indigenous infants hospitalized with bronchiolitis: a multicentre, randomized, placebo-controlled trial.-
dc.typeJournal Article-
dc.relation.incollectionDept of Health Digital Library
dc.relation.incommunityE-Books
dc.view.styleebooks
dc.identifier.journaltitleFrontiers in pediatrics-
dc.identifier.doi10.3389/fped.2015.00032-
dc.identifier.pubmedidhttps://ezpdhcs.nt.gov.au/login?url=https://www.ncbi.nlm.nih.gov/pubmed/25954737-
dc.identifier.affiliationChild Health Division, Menzies School of Health Research, Charles Darwin University , Darwin, NT , Australia..-
dc.identifier.affiliationChild Health Division, Menzies School of Health Research, Charles Darwin University , Darwin, NT , Australia ; Department of Paediatrics, Royal Darwin Hospital , Darwin, NT , Australia..-
dc.identifier.affiliationMenzies Health Institute Queensland, Griffith University and Gold Coast University Hospital , Gold Coast, QLD , Australia..-
dc.identifier.affiliationDepartment of Paediatrics, Royal Darwin Hospital , Darwin, NT , Australia..-
dc.identifier.affiliationDepartment of Paediatrics, Townsville Hospital , Townsville, QLD , Australia..-
dc.identifier.affiliationChild Health Division, Menzies School of Health Research, Charles Darwin University , Darwin, NT , Australia..-
dc.identifier.affiliationQueensland Paediatric Infectious Diseases Laboratory, Queensland Children's Medical Research Institute, Sir Albert Sakzewski Virus Research Centre, Children's Health Queensland Hospital and Health Service, University of Queensland , Herston, QLD , Australia..-
dc.identifier.affiliationQueensland Paediatric Infectious Diseases Laboratory, Queensland Children's Medical Research Institute, Sir Albert Sakzewski Virus Research Centre, Children's Health Queensland Hospital and Health Service, University of Queensland , Herston, QLD , Australia ; Clinical Medical Virology Centre, School of Chemistry and Molecular Biosciences, University of Queensland , St Lucia, QLD , Australia..-
dc.identifier.affiliationChild Health Division, Menzies School of Health Research, Charles Darwin University , Darwin, NT , Australia..-
dc.identifier.affiliationChild Health Division, Menzies School of Health Research, Charles Darwin University , Darwin, NT , Australia..-
dc.identifier.affiliationChild Health Division, Menzies School of Health Research, Charles Darwin University , Darwin, NT , Australia..-
dc.identifier.affiliationDepartment of Paediatrics, Townsville Hospital , Townsville, QLD , Australia..-
dc.identifier.affiliationThe University of Auckland and Starship Children's Hospital , Auckland , New Zealand..-
dc.identifier.affiliationThe University of Auckland and Starship Children's Hospital , Auckland , New Zealand..-
dc.identifier.affiliationChild Health Division, Menzies School of Health Research, Charles Darwin University , Darwin, NT , Australia ; Queensland Children's Medical Research Institute, Children's Health Queensland, Queensland University of Technology , Brisbane, QLD , Australia..-
dc.identifier.pubmedurihttps://ezpdhcs.nt.gov.au/login?url=https://www.ncbi.nlm.nih.gov/pubmed/25954737-
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